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. 2016 Dec 21;25(3):332–340. doi: 10.1038/ejhg.2016.169

Figure 5.

Figure 5

HTT haplotype distribution of HD and control chromosomes in Latin American HD families from the UBC HD BioBank. Amerindian A1 is the most frequent HD haplotype in a collection of patients from across Latin America (47%). The parent A1 haplotype, which could be therapeutically targeted for allele-specific HTT silencing in European patient populations, constitutes the majority (59%) of HD chromosomes in Latin American patients. Latin American control haplotypes reflect indigenous Amerindian and European admixture.