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. 2016 Oct 4;6(10):e910. doi: 10.1038/tp.2016.181

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Copyright © 2016 The Author(s)

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Chronic unpredictable mild stress (CUMS) leads the mice to express depression-like behaviors. Mice were subjected to the adaptation for a week, the CUMS for 3 weeks and the behavioral tests in 3 days. Behavioral tests show the significant decreases in sucrose preference (a) and the ratios of stay time in the M-arm to stay time in three arms (b) as well as an increase in immobile time (c) from CUMS-induced depression mice (n=33) and controls (n=30). The results are expressed as mean±s.e.m. ***P<0.001.