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. 2016 Oct 18;6(10):e920. doi: 10.1038/tp.2016.195

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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In a biphasic manner, cannabidiol inhibited the binding of [³H]domperidone to dopamine D2 receptors in rat brain homogenized striata, similar to the biphasic pattern for other dopamine agonists and the partial dopamine agonist antipsychotic aripiprazole. The earlier published data for aripiprazole¹² are redrawn here to show the similarity to cannabidiol. Olanzapine (redrawn from Seeman et al.¹³) and all other antipsychotic antagonists do not reveal a biphasic pattern when using any antagonist radioligand for D2.