Skip to main content
. 2016 Dec 6;6(12):e972. doi: 10.1038/tp.2016.223

Figure 4.

Figure 4

Leptin signaling in CeA is critical for anxiety but not cocaine-conditioned reward. (a) Representative images of the AAV-CAG-EGFP-T2A-Cre-infected CeA from Leprflox/flox mice and WT littermates. EGFP: green; LepR: red; arrows indicate the EGFP+ cells. Scale bar, 100μm (low-magnification images) and 20 μm (high-magnification images). (b) Quantification of the percentage of LepR-positive cells in the EGFP+ population in the CeA of virus-infected Leprflox/flox mice and WT mice. (c) Quantification of the place preference scores of Leprflox/flox and WT mice in the pre-test and test sessions. (d) Time spent in the open arms of the elevated plus maze test in the Leprflox/flox and WT mice. (e) Time in the center zone of the open-field test in the Leprflox/flox and WT mice. The data are presented as the mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001. CeA, central amygdala; LepR, leptin receptor; WT, wild-type.