Table 5. Excess relative risk coefficients for circulatory diseases as a result of radiation exposure, by disease endpoint.
Values for the analysis are from Tables 1-3, using 5-year lag whenever possible, and restricting to <0.5 Gy for the TB fluoroscopy cohorts, whenever possible. Thyroid dose (a surrogate for dose to the carotid artery) is used for cerebrovascular disease, whenever possible. Random effects models are fitted via restricted maximum likelihood (REML).
| Disease (ICD Code) | Studies/detailed endpoints | Random-effect estimate ERR Sv-1 (95% CI) | 1-sided significance, p-value | Heterogeneity p-value |
|---|---|---|---|---|
| Ischemic heart disease (ICD10 I20-I25) | Yamada et al [23], Ivanov et al [60], Vrijheid et al [59], Muirhead et al [73], Mulrooney et al [35] [myocardial infarction], Lane et al [76], Laurent et al [77], Shimizu et al [24] [underlying cause], Little et al[17], Darby et al [46] [EQD2 heart dose], Krestinina et al [79] [5 year lag], Kreuzer et al [75], Zablotska et al [50] [<0.5 Gy], Azizova et al [32] [5 year lag, morbidity data], Little et al [51][< 0.5 Gy], van Nimwegen et al [47] | 0.082 (0.057, 0.106) | <0.0001 | 0.4430 |
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| Non-ischemic heart disease (ICD10 I26-I52) | Ivanov et al [60], Vrijheid et al [59] [heart failure], Mulrooney et al [35] [congestive heart failure, pericardial disease, valvular disease], Shimizu et al [24] [heart failure (ICD9 428)(underlying cause), other heart disease (ICD9 390-392, 415-427, 429)(underlying cause)], Cutter et al [34][valvular heart disease], Little et al [51] | 0.094 (0.078, 0.111) | <0.0001 | 0.2041 |
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| Cerebrovascular disease (ICD10 I60-I69) | Yamada et al [23], Vrijheid et al [59], Muirhead et al [73], Lane et al [76], Laurent et al [77], Shimizu et al [24] [underlying or contributing cause], Grosche et al [80][exposed settlements only, 10 year lag], Little et al [17] [thyroid dose], Kreuzer et al [75], Moseeva et al [33][5 year lag, morbidity data], Kashcheev et al [61], Little et al [51] [thyroid dose, <0.5 Gy] | 0.236 (0.062, 0.410) | 0.0040 | <0.0001 |
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| Circulatory disease apart from heart disease and stroke (ICD10 I00-I19, I53-I59, I70-I99) | Yamada et al [23] [hypertension (linear model), hypertensive heart disease, aortic aneurysm], Ivanov et al [60] [diseases of arteries, arterioles and capillaries (ICD10 I70-I79), hypertension (ICD10 I10-I15), disease of veins, lymphatic vessels and lymph nodes (ICD10 I80-I89)], Shimizu et al [24] [underlying or contributing cause], Little et al [51] | 0.137 (-0.049, 0.322) | 0.0745 | <0.0001 |
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| All circulatory disease (ICD10 I00-I99) | Yamada et al [23] [hypertension (linear model), hypertensive heart disease, IHD, CeVD, aortic aneurysm], Ivanov et al [60] [hypertension (ICD10 I10-I15), IHD, other heart disease (ICD10 I30-I52), diseases of arteries, arterioles and capillaries (ICD10 I70-I79), disease of veins, lymphatic vessels and lymph nodes (ICD10 I80-I89)], Vrijheid et al [59], Muirhead et al [73], Mulrooney et al [35] [congestive heart failure, pericardial disease, valvular disease, myocardial infarction], Lane et al [76] [IHD, CeVD, other circulatory disease], Laurent et al [77], Shimizu et al [24] [underlying or contributing cause], Tukenova et al (2010)[cardiac disease], Grosche et al [80] [exposed settlements only, 10 year lag], Little et al [17], Darby et al [46] [EQD2 heart dose], Krestinina et al [79] [5 year lag], Kreuzer et al [75], Moseeva et al [33] [5 year lag, morbidity data], Zablotska et al [50] [5 year lag], Azizova et al [32] [5 year lag, morbidity data], Cutter et al [34], Kashcheev et al [61] [CeVD], Little et al [51] [< 0.5 Gy], van Nimwegen et al [47] | 0.115 (0.064, 0.167) | <0.0001 | <0.0001 |