Table 6. Results of meta-regression analyses adjusting for age at exposure, dose fractionation/dose rate, mean dose.

Random effects models are fitted via maximum likelihood. Optimal model (with lowest AIC) is given in boldface and underlined. For ischemic heart disease and cerebrovascular disease models are fitted using Mayak morbidity data (main analysis) or Mayak mortality data (subsidiary analysis)

	Ischemic heart disease (Mayak morbidity)			Ischemic heart disease (Mayak mortality)			Heart disease other than ischemic heart disease			Cerebrovascular disease (Mayak morbidity)			Cerebrovascular disease (Mayak mortality)			Other circulatory disease
	AIC	p-valuea	I2 (%)	AIC	p-valuea	I2 (%)	AIC	p-valuea	I2 (%)	AIC	p-valuea	I2 (%)	AIC	p-valuea	I2 (%)	AIC	p-valuea	I2 (%)
Unadjusted	-20.28	0.4430	3.17	-24.09	0.7443	0.00	-14.63	0.2041	7.52	18.69	<0.0001	73.10	16.04	0.0226	57.00	4.75	<0.0001	88.99
Adjusted for age at exposure	-18.82	0.6654	0.00	-17.29	0.5380	0.00	-11.04	0.1305	8.76	11.09b	0.3717	0.02	17.22	0.0184	39.77	6.75	<0.0001	89.98
Adjusted for radiation dose fractionation	-22.95c	0.8161	0.00	-20.67	0.6494	0.00	-12.77	0.1834	9.81	15.44d	0.1545	0.00	19.36	0.0111	42.24	8.41	<0.0001	90.14
Adjusted for mean dose	-20.63	0.5483	0.00	-22.28	0.6918	0.00	-13.70	0.1972	6.49	15.97e	0.0858	24.83	17.82	0.0226	41.10	6.43	<0.0001	88.98
Adjusted for age at exposure, radiation dose fractionation	-18.11	0.8132	0.00	-16.22	0.6384	0.00	-11.43	0.1917	9.19	14.67f	0.2372	0.00	20.75	0.0075	43.51	8.41	<0.0001	90.14
Adjusted for age at exposure, mean dose	-17.48	0.6416	0.00	-15.38	0.4558	0.00	-11.43	0.1919	9.19	11.07g	0.4557	0.01	13.61h	0.2517	0.00	8.41	<0.0001	90.14
Adjusted for radiation dose fractionation, mean dose	-21.65	0.8077	0.00	-19.38	0.6318	0.00	-13.26	0.2812	7.73	14.35i	0.2592	0.01	16.94	0.1232	0.01	8.41	<0.0001	90.14
Adjusted for age at exposure, radiation dose fractionation, mean dose	-16.44	0.7668	0.00	-16.47	0.7856	0.00	-9.43	0.1071	11.99	14.77j	0.2904	0.01	16.65	0.1672	0.01	0.41	<0.0001	90.14

^ap-value of residual heterogeneity

^bsignificant improvement in fit over null model (p=0.0019);

^csignificant improvement in fit over null model (p=0.0357);

^dsignificant improvement in fit over null model (p=0.0267);

^esignificant improvement in fit over null model (p=0.0299);

^fsignificant improvement in fit over null model (p=0.0184);

^gsignificant improvement in fit over null model (p=0.0030);

^hsignificant improvement in fit over null model (p=0.0402);

ⁱsignificant improvement in fit over null model (p=0.0159);

^jsignificant improvement in fit over null model (p=0.0179).