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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Pathol. 2017 Jan 6;241(4):501–510. doi: 10.1002/path.4854

Figure 1.

Figure 1

Mdm4 overexpression accelerates tumorigenesis in p53R172H/+mice. Kaplan-Meier survival curves of Mdm4Tg6 (n=53), Mdm4Tg15 (n=49), p53R172H/+ (n=58), Mdm4Tg6 p53R172H/+ (n=47), Mdm4Tg15 p53R172H/+ (n=43), and p53R172H/R172H (n=53) mice with BALB/cJ background. (B) The tumour spectrum of Mdm4Tg6, Mdm4Tg15, Mdm4Tg6, p53R172H/+ and Mdm4Tg15 p53R172H/+ mice presented as the percentage of each tumour type out of the total number of tumours for each genotype. The total number of tumours examined by pathologists for each genotype is indicated in parentheses above each bar. (C) Overexpression of Mdm4 increased multiple tumour incidences in the double mutant mice. ** indicates p<0.01 and *** indicates p < 0.001.