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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Pathol. 2017 Jan 6;241(4):501–510. doi: 10.1002/path.4854

Figure 5.

Figure 5

Mdm4 overexpression reveals p53 independent function. (A) Similar Kaplan-Meier survival curves of p53−/− (n=51), Mdm4Tg1 p53−/− (n=36) and Mdm4Tg15 p53−/− (n=28). (B) Mdm4Tg15 p53−/− male mice (n=25) had significant shorter survival than p53−/− male mice (n=15). (C) Mdm4Tg15 p53−/− mice had higher incidence of multiple tumours. (D) Positive IHC staining for Mdm4 in a representative Mdm4Tg15 p53−/− haemangiosarcoma. (E) Overexpression of Mdm4 in two p53−/− primary tumour cell lines (No. 32 and No. 46) accelerated cell proliferation (F). ** and *** indicate p <0.01 and p <0.001, respectively.