Table 3.

Hemodynamic responses to intra-arterial infusion of sodium nitroprusside.

	Protocol 1		Protocol 3
	Control	SDF	Control	SDF+LNMMA
Heart Rate (beat/min)
Baseline	61 ± 3	63 ± 4	59 ± 2	59 ± 3
0.25 µg/dL/min	61 ± 4	63 ± 5	59 ± 2	56 ± 2
0.5 µg/dL/min	59 ± 4	62 ± 5	60 ± 2	56 ± 2
1.0 µg/dL/min	61 ± 4	64 ± 5	60 ± 3	60 ± 3
2.0 µg/dL/min	63 ± 5abcd	67 ± 5abcd	62 ± 3abc	62 ± 2abc
Mean Arterial Blood Pressure (mmHg)
Baseline	90 ± 3	88 ± 2	89 ± 3	89 ± 3
0.25 µg/dL/min	89 ± 2	86 ± 2	86 ± 3a	87 ± 3a
0.5 µg/dL/min	87 ± 3a	86 ± 2a	84 ± 3ab	85 ± 3ab
1.0 µg/dL/min	86 ± 2a	84 ± 2a	83 ± 3ab	83 ± 3ab
2.0 µg/dL/min	85 ± 3abc	84 ± 2abc	80 ± 3abcd	81 ± 3abcd
Brachial Artery Diameter (cm)
Baseline	0.36 ± 0.02	0.36 ± 0.02	0.32 ± 0.02	0.32 ± 0.02
0.25 /dL/min µg	0.37 ± 0.02	0.37 ± 0.02	0.33 ± 0.01a	0.33 ± 0.02a
0.5 µg/dL/min	0.37 ± 0.02a	0.37 ± 0.02a	0.34 ± 0.02ab	0.33 ± 0.02ab
1.0 µg/dL/min	0.37 ± 0.02ab	0.39 ± 0.02ab	0.35 ± 0.02abc	0.35 ± 0.02abc
2.0 µg/dL/min	0.38 ± 0.02abc	0.39 ± 0.02abc	0.35 ± 0.02abcd	0.36 ± 0.02abcd
Forearm Blood Flow (mL/dL forearm volume/min)
Baseline	5±1	9±2	10±3	5±1
0.25 µg/dL/min	19±3a	31±4a†	24±3a	20±2a
0.5 µg/dL/min	22±4a	31±6a	31±4ab	31±4ab
1.0 µg/dL/min	28±5a	41±7a†	39±5abc	39±4abc
2.0 µg/dL/min	35±6abc	54±10abcd†	49±6abcd	52±6abcd
AUC	41±7	61±11†	53±5	62±7†
Forearm Vascular Conductance (mL/dL forearm volume/min/100 mmHg)
Baseline	6±1	10±2	12±3	6±1
0.25 µg/dL/min	21±4a	36±5a†	28±4a	24±2a
0.5 /dL/min µg	26±5a	36±7a	38±4ab	38±4ab
1.0 µg/dL/min	32±6a	49±9a†	49±5abc	48±5abc
2.0 µg/dL/min	41±6abc	65±13abcd†	64±6abcd	65±7abcd
AUC	48±8	73±13†	67±6	78±8†

^ap<0.05 vs Baseline,

^bp<0.05 vs 0.25 µg/dL/min,

^cp<0.05 vs 0.5 µg/dL/min,

^dp<0.05 vs 1.0 µg/dL/min;

^†p<0.05 vs Control.

AUC = Area Under the Curve (AU).