Table 1. Demographic, clinical and physiologic data, stratified by survival.
| Clinical factor | Overall (N=363) | Survived (N=261) | Died (N=102) | P |
|---|---|---|---|---|
| Age (years) | 48 (38-61) | 46 (37-58) | 52 (41-67) | 0.002 |
| Male gender | 190 (52%) | 133 (51%) | 57 (56%) | 0.4 |
| Caucasian race | 238 (66%) | 182 (70%) | 56 (55%) | 0.008 |
| Body-surface area (m2) | 1.9 (1.8-2.2) | 2.0 (1.8-2.2) | 1.9 (1.7-2.0) | 0.003 |
| Vasopressor use (%) | 118 (33%) | 73 (28%) | 45 (44%) | 0.003 |
| Cause of ARDS (primary) | ||||
| trauma | 27 (7%) | 21 (8%) | 6 (6%) | 0.5 |
| sepsis | 78 (21%) | 52 (20%) | 26 (25%) | 0.2 |
| aspiration | 52 (14%) | 41 (16%) | 11 (11%) | 0.2 |
| pneumonia | 182 (50%) | 129 (49%) | 53 (52%) | 0.7 |
| other (ie, pancreatitis, fat embolism syndrome, near drowning, idiopathic) | 21 (6%) | 16 (6%) | 5 (5%) | 0.7 |
| APACHE III score | 93 (70-115) | 86 (64-106) | 109 (91-131) | 0.00001 |
| Tidal volume (mL) | 450 (400-520) | 450 (390-514) | 450 (400-544) | 0.4 |
| PEEP (cm H2O) | 10 (5-12) | 10 (5-12) | 8 (5-12) | 0.9 |
| Plateau pressure (cm H2O) | 26 (22-30) | 26 (22-30) | 27 (22-31) | 0.4 |
| Driving pressure (cmH2O) | 16 (13-20) | 16 (13-20) | 17 (13-23) | 0.3 |
| Peak pressure (cm H2O) | 32 (27-38) | 32 (26-37) | 33 (27-39) | 0.3 |
| Fraction of inspired oxygen | 0.6 (0.5-0.8) | 0.6 (0.5-0.8) | 0.6 (0.5-0.8) | 0.3 |
| Arterial pH | 7.37 (7.3-7.43) | 7.37 (7.31-7.43) | 7.37 (7.28-7.42) | 0.3 |
| Arterial pCO2 | 39 (34-45) | 40 (34-45) | 39 (33-44) | 0.4 |
| A-a gradient | 287 (200-411) | 281 (191-406) | 319 (210-434) | 0.2 |
| PaO2/fIO2 ratio | 146 (100-200) | 148 (102-200) | 138 (88-202) | 0.3 |
| Arterial pO2 | 82 (68-103) | 82 (68-103) | 78 (66-104) | 0.4 |
Data shown as median (IQR) or N(%). ARDS: acute respiratory distress syndrome; APACHE: acute physiology and chronic health evaluation; PEEP: positive end-expiratory pressure; A-a: alveolar-arterial