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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Parasitol Res. 2016 Dec 24;116(3):827–838. doi: 10.1007/s00436-016-5350-5

Figure 3. Insulin and glucagon secretion in Chagasic patients compared to healthy controls.

Figure 3

Comparison of plasma insulin levels (+/− SEM) in Chagasic and non-Chagasic patients after a 100 g oral D-glucose challenge (graphical representation of data from Long RG et al (42) reveals that in parallel to the report in mouse models (8), infection attenuates both early and prolonged phases of insulin output in humans (A). Glucose regulates pancreatic islet α and β cells in opposite directions: it is stimulatory for insulin release and inhibitory for glucagon secretion. Despite similar plasma concentrations of the incretin GIP secreted from the intestine (not shown), pancreatic glucagon release in individuals with Chagas disease is exaggerated (B).