Table 2. DNA repair and cell cycle genes robustly correlated with survival of BC cell lines to DT01 and olaparib.
| Gene name | Correlation with survival to
|
|
|---|---|---|
| AsiDNA | Olaparib | |
| PPP2R5C | 0.88 | 0.35 |
| CCNA1 | 0.82 | 0.13 |
| FANCE | 0.78 | 0.43 |
| CUL1 | 0.72 | 0.10 |
| MRE11A | 0.69 | 0.25 |
| MAX | 0.67 | 0.31 |
| XRCC1 | -0.63 | 0.19 |
| PPP2R5D | -0.82 | -0.4 |
| AKT3 | -0.83 | -0.4 |
|
| ||
| ATR | 0.41 | 0.82 |
| MBD4 | 0.35 | 0.79 |
| TP53 | -0.32 | 0.78 |
| NEDD4 | 0.15 | 0.77 |
| PRKCH | 0.28 | 0.75 |
| PPP2R5E | 0.42 | 0.75 |
| STAG2 | 0.39 | 0.75 |
| RAD51C | 0.09 | 0.66 |
| ABL1 | 0.32 | -0.51 |
| SMC5 | 0.24 | -0.55 |
| POLB | -0.15 | -0.67 |
| MCPH1 | 0.35 | -0.74 |
| NEIL2 | -0.43 | -0.81 |
| PRKCB | 0.011 | -0.83 |
Numbers indicate correlation coefficients (Spearman r; P value <0.005) between expression of DNA repair and cell cycle-involved genes and survival to AsiDNA or olaparib. (Pale grey: non-significant correlation).