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. Author manuscript; available in PMC: 2018 Feb 17.
Published in final edited form as: ACS Chem Biol. 2016 Dec 29;12(2):494–503. doi: 10.1021/acschembio.6b00918

Table 1.

Relative Binding Affinities (RBA values; estradiol RBA = 100) of OBHS analogs for the ERα and ERβ.a

Entry Compd. ERα ERβ α/β ratio
1 graphic file with name nihms836365t1.jpg 9.3 ± 0.6 1.7 ± 0.2 5.4
2 graphic file with name nihms836365t2.jpg 0.064 ± 1.5 0.096 ± 6.4 0.66
3 4.28 ± 0.35 0.55 ± 0.45 7.78
4 graphic file with name nihms836365t3.jpg 0.032 ± 4.0 0.114 ± 26 0.28
5 0.05 ± 1.9 0.08 ± 13 0.62
6 graphic file with name nihms836365t4.jpg 0.178 ± 0.04 0.0244 ± 0.01 7.3
7 0.307 ± 0.05 0.058 ± 0.01 5.3
8 graphic file with name nihms836365t5.jpg 0.149 ± 0.02 0.096 ± 0.03 1.55
9 25.8 ± 7.1 1.21 ± 0.23 21.32
graphic file with name nihms836365t6.jpg 8.24 ± 0.88 0.424 ± 0.04 19.4
a

For each of the pairs of structures in entries 2–9, only one enantiomer is shown. Structures of the individual isomers can be obtained by reference to prior figures.