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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: Clin Cancer Res. 2016 Aug 17;23(4):1049–1059. doi: 10.1158/1078-0432.CCR-15-2921

Figure 1. Ibrutinib-induced cell death in purified paired CLL cells (ibrutinib dose-response curves).

Figure 1

CD19+ CLL cells purified through negative selection were incubated with escalating doses of ibrutinib for 72 hours and the apoptotic and necrotic cell population measured using annexinV/PI staining and FACS. Displayed is the viable double-negative (DN) cell fraction normalized to the individual DN fraction measured in the solvent only controls. The mean of duplicate drug incubations and measurements is displayed. A: pre-treatment CLL samples; B: post-treatment (relapsed) CLL samples.