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Insights into the substrate specificity of the 5-tryptophan halogenase MibH. (a) Cartoon representation of the overall structure of (left) MibH and (right) PyrH49 (PDB 2WET) with their respective substrate binding clefts shown as red surfaces. Color scheme is the same as in Figure 5. (b) Surface representation of the proposed Trp binding site (dashed white line) in (left) MibH and (right) PyrH colored by hydrophobicity.
