Fig. 1.
Preliminary dose-response study of phrenic and hypoglossal nerve amplitude changes 90 min after A2A agonist (CGS-21680) injections. A: integrated phrenic amplitude 90 min post-CGS-21680. B: integrated hypoglossal amplitude 90 min post-CGS-21680. The dose chosen was 200 μM since the phrenic response was robust (A; n = 5) but without significant response in the hypoglossal burst amplitude (B; n = 3). The lack of hypoglossal response assures us that the drug is not reaching the brain stem at an effective dose.