Table 5.

Correlation of the timing of fatal symptoms/signs with other symptoms/signs among seven non-survivors after EV-A71 infection with neurological involvement

Variable	CRT Extension	Fatigue/Sleepiness	Anxiety	Hyperventilation	Tachycardia	Vomit	Persistent Hyperpyrexia	Nystagmus	Myoclonic jerks/tremor	Startle	Dysphoria	Fright
N	27	115	39	8	12	74	28	16	162	211	17	14
Mean (hours)	52.9	44.0	40.1	57.5	49.6	35.0	40.2	51.8	33.3	30.0	44.2	45.7
SD	25.4	26.5	31.1	31.5	26.3	25.2	27.4	28.5	23.0	23.0	23.1	22.1
Range	18–114	0–136	0–136	12–120	24–120	0–96	0–96	18–99	0–96	0–84	0–96	0–72
p
Autokinetic eyeball	0	0.014	0.03	0.078	0	0.047	—	0.064	0.053	0.229	—	—
Ataxia eyeball	0.001	0.002	0.008	0.003	0	0.017	—	0.003	0.053	0.03	—	—
Ultrahyperpyrexia	0.002	—	—	—	0	—	0.002	—	—	—	—	—
Pharyngeal reflex decreased or absent	0.002	0.056	0.024	0.015	—	0.05	0.161	0.008	0.256	0.172	—	—
Respiratory rhythm abnormally	0	0.004	0.006	0	0	0.012	0.029	0.104	0.048	0.094	0.011	0.278
NPE	0	0	0.013	0.001	0	0.066	0.003	0.091	0.007	0.089	0.003	0.206
Severe coma	0	0.047	—	—	—	0.009	—	—	0.021	0.006	—	0.029
Excessive Tachycardia	0.001	0.034	0.024	—	—	0.454	0.061	0.033	0.127	0.412	—	—
Refractory shock	0	0.033	0.075	0.029	—	0.182	—	0.104	—	0.15	0.053	0.074
Ataxia respiratory	0	0.038	—	—	—	0.362	0.043	—	0.102	0.334	—	—
N (P < 0.05)	10	8	6	5	5	5	4	4	3	2	2	1