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. 2017 Feb 18;10:50. doi: 10.1186/s13045-017-0418-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Paxillin at focal adhesions. As a major component of FAs, the phosphorylation of paxillin by FAK upon integrin activation allows the recruitment of several enzymes and structural molecules. Dynamics of paxillin association with these molecules results in changes in cell movement and migration. The figure depicts a simplified scheme showing the main components of a focal adhesion complex. The number and composition of the FA complex and the related signaling pathways may vary in different scenarios, according to the subunit composition of integrin receptors and the specific signaling pathways activated by distinct combinations, in addition to the type and developmental stage of the cell [44]