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. 2017 Feb 17;16:80. doi: 10.1186/s12936-017-1725-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of SKM13 on haematological parameters of P. berghei. The effect of SKM13 on haematological indices was examined every 3 days after treatment. At day 6, the WBC count of both of P. berghei NK65 and NAT strains significantly increased, and the other three parameters (red blood cell, haemoglobin, and haematocrit) decreased from 3 days after infection. Treatment of SKM13 (20 mg/kg) suppressed the changes of WBC, RBC, haemoglobin, and haematocrit compared with the infected group from 1 to 12 days (*P < 0.05, ***P < 0.0001). The values shown are the mean ± SD