Table 2.

Clinical findings and treatment outcomes in eight cases of WD with osseomuscular type

No	K-F ring	Neurologic Examination			CP (g/L)	Involvement on brain MRI	Abdominal ultrasonography	Outcomes of Chelation Therapy (Degreea)
		Strength	Tone	Reflex
1	+	UE & LE 5	UE ↑	(++)	<0.02	Basal ganglia	Hepatic diffuse disease	(9 months after treatment) Dystonia in the right hand partially relieved; blurred speech persist; walking better (2)
2	+	UE & LE 5	Normal	(++)	0.02	Basal ganglia and brain stem	Hepatic diffuse disease, splenomegaly	(3 months after the treatment) Pain relieved with improved speech (0)
3	+	UE & LE 5	Normal	(++)	<0.02	Normal	Hepatic diffuse disease, splenomegaly	(14 months after treatment) Pain relieved (0)
4	+	UE & LE 5	UE & LE ↑	(++)	0.07	N/A	Hepatic diffuse disease	(after 23 months of inconsecutive treatment) No obvious improvement (3)
5	N/A	UE & LE 5	UE ↑	UE & LE (+++)	0.03	Basal ganglia and brain stem	Hepatic diffuse disease, splenomegaly	N/A
6	+	UE & LE 5	UE & LE ↓	(++)	0.03	N/A	Normal	N/A
7	+	UE 5; pLE 4; dLE 4-	UE & LE ↓	Knee (+++)	0.02	N/A	Hepatic diffuse disease, splenomegaly	N/A
8	-	UE 4; LE 4-	LE ↑	Knee (+++)	0.05	Normal	Increased echogenicity	(6 months after treatment) Pain relieved with improved joint motion (2)

UE upper extremity, LE lower extremity, dLE distal lower extremity, pLE proximal lower extremity, CP ceruloplasmin, N/A not available

^aBased on the published assessment scale for osseomuscular symptoms [7]