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. 2017 Feb 18;36:32. doi: 10.1186/s13046-017-0497-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Model to explain Che-1 involvement in HIF-1α stabilization. Under hypoxic conditions the depletion of Che-1 leads to a decrease of the ubiquitin E3 ligase SIAH2, allowing an increase of the prolyl isomerase PHD3. This results in a decrease of HIF-1α stabilization (bottom)