Table 2.
TTG-IgA antibody screening and diagnostic test performance
| TTG-IgA xULN (n) | PPV | NPV | Sens | Spec |
|---|---|---|---|---|
| 1 (763) | 61 | 98 | 90 | 90 |
| 2 (535) | 79 | 97 | 82 | 96 |
| 3 (430) | 89 | 96 | 74 | 99 |
| 4 (380) | 92 | 95 | 68 | 99 |
| 5 (343) | 93 | 94 | 62 | 99 |
| 6 (278) | 95 | 92 | 51 | 100 |
| 7 (221) | 96 | 91 | 41 | 100 |
| 8 (127) | 97 | 89 | 24 | 100 |
| 9 (100) | 98 | 88 | 19 | 100 |
| 10 (80) | 98 | 88 | 21 | 100 |
AUROC, area under receiver operator characteristic curve; IgA, immunoglobulin A; NPV, negative predictive value; PPV, positive predictive value; Sens, sensitivity; Spec, specificity; TTG, tissue transglutaminase; ULN, upper limit of normal