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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Int J Cardiol. 2017 Jan 4;232:12–23. doi: 10.1016/j.ijcard.2017.01.015

Table 7.

Major prospective randomized clinical trials of online hemodiafiltration and survival outcomes

First author,
year (ref #)		 Inclusion
criteria		 Intervention Duration,
years		 Composite fatal and
non-fatal cardiovascular
events (%)		 All-cause mortality (%) Cardiovascular mortality
(%)
OL-HDF Conventional
HD		 HR
(95%
CI)		 OL-HDF Conventional
HD		 HR
(95%
CI)		 OL-HDF Conventional
HD		 HR
(95%
CI)
CONSTRAST, 2012 (126). Maintenance HD (n=714) Online post-dilution hemodiafiltration vs. low-flux hemodialysis 3 32.4 31.5 1.07 (0.83–1.39) 36.6 38.8 0.95 (0.75–1.20) 10.3 12.9 0.80 (0.52–1.24)
Turkish OL-HDF, 2013 (129).. Maintenance HD (n=782) Online post-dilution hemodiafiltration vs. high-flux hemodialysis 2 22.4 25.2 0.82 (0.59–1.16) 13.3 16.6 0.79 (0.55–1.14) 8.1 11.2 0.72 (0.45–1.13)
ESHOL, 2013 (130). Maintenance HD (n=906) Online post-dilution hemodiafiltration vs. high-flux hemodialysis 3 NA NA NA 18.6 27.1 0.70 (0.53–0.92) 8.1 12.2 0.67 (0.44–1.02)