PA28αOE improved cardiac function in diabetic mice. Invasive hemodynamic measurements were obtained in CTL and PA28aOE mice 8 weeks after STZ injection. Results of pressure-volume (PV) loop analyses showing measures of systolic (A–D) and diastolic (E–H) function. dP/dt max, maximal dP/dt; Pes, end-systolic pressure; Ves, end-systolic volume; EF, ejection fraction; dP/dt min, minimal dP/dt; Ped, end-diastolic pressure; Ved, end-diastolic volume; Tau, the load-independent isovolumic relaxation constant. N=7–9 mice per group. Data are expressed as Mean+SEM. **P<0.01 versus CTL; #P<0.05, ##P<0.01 versus CTL+STZ, respectively.