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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Brain Behav Immun. 2016 Dec 20;61:80–95. doi: 10.1016/j.bbi.2016.12.016

Figure 1. Prenatal alcohol exposure (PAE) potentiates allodynia in adult rats following Chronic Constriction Injury (CCI).

Figure 1

Absolute threshold behavioral responses for (a) ipsilateral and (b) contralateral hindpaws are shown. At baseline (BL), responses to low threshold mechanical stimuli were similar in all groups (ipsilateral, F1,36= 1.877, P =0.179; contralateral, F1,36= 1.228, P = 0.275), regardless of PAE or saccharin (Sac) treatment. Statistics show a main effect of alcohol exposure from data collected from the ipsilateral hindpaw [F1,36 = 12.009, P = 0.001] but not in the contralateral hindpaw [F1,36 = 4.169, P = 0.049]. There was a main effect of CCI surgery [ipsilateral, F1,36 = 311.943, P < 0.001; contralateral, F1,36 = 54.554, P < 0.001]. In addition, an interaction between alcohol exposure and CCI surgery only in the ipsilateral hindpaw [ipsilateral, F1,36 = 5.246, P = 0.028; contralateral, F1,36 = 1.383, P = 0.247] is observed. Comparison of treatment groups post-surgery demonstrate a larger increase in sensitivity following CCI in PAE animals compared to their Sac-CCI counterparts where a main effect of alcohol exposure in the ipsilateral hindpaw [ipsilateral, F1,36 = 12.938, P = 0.001; contralateral, F1,36 = 4.003, P = 0.053] is observed. In addition, a main effect of CCI surgery [ipsilateral, F1,36 = 347.595, P < 0.001; contralateral, F1,36 = 58.406, P < 0.001] and an interaction of alcohol exposure and CCI surgery in the ipsilateral paw [ipsilateral, F1,36 = 8.312, P = 0.007; contralateral, F1,36 = 1.928, P = 0.174] was revealed. N=10 rats in each group.