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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: BJU Int. 2016 Sep 18;120(5B):E30–E44. doi: 10.1111/bju.13631

Figure 5. CTC size varies greatly across patients with mCRPC.

Figure 5

A. Cellular area (μm2) per CTC as calculated by Epic software for each patient is plotted. White blood cell (WBC) size frequency distribution curve was generated by measuring the cellular area of approximately 300 normal WBCs (right side). The blue dashed line represents the median WBC area (75 μm2). Red and green dashed lines indicate WBC size cut-offs equal to the 25th (64 μm2) and 75th (90 μm2) percentile, respectively. Traditional CTCs (blue), CTC clusters (green) and CK− CTCs (purple) are indicated according to the legend. Apoptotic CTCs were omitted from analysis due to poor segmentation of fragmented nuclei in these cells. B. The percentage of all CTCs for each patient with area greater than (non-Small CTC; green) or less than the WBC 75th percentile (Small CTC; red) is plotted. *Sample 5037 was not evaluable and is not included in panel A.