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Mean peak ASR startle response for prepulse inhibition (PPI) with a visual prepulse is presented as a function of genotype (HIV-1 Tg or Control) and age (± SEM). A significant age x interstimulus interval (ISI) x genotype interaction was observed. HIV-1 Tg animals exhibit alterations in the development of perceptual sharpening, evidenced by their flatter ISI function.
