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Mean peak ASR startle response for prepulse inhibition (PPI) with an auditory prepulse is presented as a function of genotype (HIV-1 Tg or Control) and age (± SEM). A significant age x interstimulus interval (ISI) x genotype interaction was present, indicating an alteration in the development of ISI function in the HIV-1 Tg animals. HIV-1 Tg animals exhibit a flatter ISI function at all test ages in comparison to control animals.
