Table 2.

Pair-wise comparison of combined and antigen-specific IFN-γ response in HIV-infected women who were IGRA-negative at enrollment (32 weeks’ gestation) and IGRA-positive/negative/indeterminate at 12 months postpartum

	Antigen-specific spot count above negative control, SFC/well
Postpartum IGRA response to M. tuberculosis antigens (number of pairs)	32 weeks’ gestation Mean (95%CI)	12 months postpartum Mean (95%CI)	P value*
Combined ESAT-6/CFP-10 response†
Positive (n = 11)	1.23 (0.07–2.38)	50.91 (12.93–88.89)	0.015
Negative (n = 53)	0.57 (0.26–0.89)	1.21 (0.78–1.63)	0.02
Indeterminate (n = 25)	1.40 (0.42–2.37)	9.33 (−4.97–23.64)	0.27
ESAT-6
Positive (n = 11)	0.59 (−0.06–1.24)	47.0 (8.67–85.33)	0.02
Negative (n = 53)	0.47 (0.17–0.78)	0.92 (0.54–1.31)	0.06
Indeterminate (n = 25)	0.44 (0.04–0.83)	7.71 (−5.88–21.29)	0.28
CFP-10
Positive (n = 11)	0.95 (−0.21–2.12)	30.73 (3.70–57.75)	0.04
Negative (n = 53)	0.26 (0.09–0.44)	0.57 (0.25–0.88)	0.11
Indeterminate (n = 25)	1.15 (0.16–2.15)	2.74 (−2.85–8.33)	0.58

^*Paired t-test.

^†IGRA response to M. tuberculosis-specific antigens.

IFN-γ = interferon-gamma; HIV = human immunodeficiency virus; IGRA = interferon-gamma release assay; SFC = spot-forming cells; CI = confidence interval; ESAT-6 = early secretory antigenic 6; CFP-10 = culture filtrate protein 10.