Table 2.

Chromatin modifiers implicated in cancer and their analogous zebrafish models

Chromatin modifier	Human cancers	Zebrafish cancer model	Mechanism of carcinogenesis in fish	References
UHRF1	Multiple	HCC	Senescence escape, genomic instability	Cui et al. (2014) [117], Mudbhary et al. (2014) [5]
DNMT1	Multiple	No	Unknown	Li et al. (2010) [118], Chen et al. (2006) [119], Xu et al. (2010) [120]
DNMT3a/b	AML, melanoma	No	Unknown	Im et al. (2014) [121], Nguyen et al. (2002) [109]
TET2	Leukemia	Myelodysplasia	Unknown	Gjini et al. (2015) [8], Scourzic et al. (2015) [122]
EZH2	Prostate, HCC, myeloma	No	Unknown	Chinaranagari et at. (2014) [110], Hung et al. (2014) [123]
SETDB1	Melanoma	Melanoma	Cooperation with BRAFV 600E	Ceol et al. (2011) [7]
SUV39H1	HCC, gastric colorectal, breast	Rhabdo- myosarcoma	Cyclin B1 repression	Albacker et al. (2013) [9], Cai et al. (2014) [124], Chiba et al. (2013) [92], Khanal et al. (2013) [125]
G9a	Squamous cell carcinoma, glioma	No	Unknown	Tao et al. (2014) [126], Zhong et al. (2015) [127]