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A and B) Comparison between DPMI-γ (yellow) and DPMI-α (green) in a Cα ribbon diagram bound to the p53-binding pocket of MDM2; C) Growth inhibition of U87 cells by Nutlin-3, free DPMI-α, liposome-DPMI-α, RGD-liposome-DPMI-α, and RGD-liposome-LPMI-α; D) Growth inhibition of U87 s.c. xenografts in nude mice by DPMI-α and doxorubicin (Adapted from ref 6, Copyright 2010 National Academy of Sciences).
