Table 2.
Toxicity.
| 3.5 mg/kg (N = 6), n |
10 mg/kg (N = 26), n |
All patients (N = 32), n |
||||
|---|---|---|---|---|---|---|
| Toxicity | ≥Grade 2 | Grades 3–4 | ≥Grade 2 | Grades 3–4 | ≥Grade 2 | Grades 3–4 |
| Hyperbilirubinemia | 2 | 1 | 5 | 2 | 7 | 3 |
| Aspartate aminotransferase increased | 6 | 4 | 5 | 3 | 11 | 7 |
| Alanine aminotransferase increased | 1 | - | 5 | 3 | 6 | 3 |
| Pruritus | - | - | 3 | 1 | 3 | 1 |
| Rash | 3 | - | 2 | - | 5 | - |
| Pneumonitis | 1 | - | - | - | 1 | - |
| Colitis | - | - | 2 | - | 2 | - |
| Angioedema | - | - | - | 1 | - | 1 |
| Thyroid dysfunction | - | - | 1 | 1 | 1 | 1 |
| Adrenal insufficiency | - | - | - | 1 | - | 1 |
| Discontinued due to toxicity | 1/6 | 3/25 | 4 (13%) | |||