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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Hepatol. 2016 Nov 18;66(3):601–609. doi: 10.1016/j.jhep.2016.11.004

Fig. 3. Aging exacerbates chronic-plus-binge-induced oxidative stress.

Fig. 3

(A) Young and middle-aged mice were treated with chronic (8wks)-plus-multiple binges as described in Fig. 2. Hepatic levels of HNE adducts and protein nitration were measured by using an ELISA kit. (B) Young and middle-aged mice were treated with chronic (10d)-plus-one binge as described in Fig. 1. Immunohistochemistry for 4-HNE was performed, magnification at 200x. Values represent means ± SEM (n= 5). *P< 0.05, **P<0.01.