Table 3.
Comparisons between TD-EF and TD-IF for healthy controls (HC) and OCD patients.
| Condition/Region (Side) | BA | k | x | y | z | Max z | k | x | y | z | Max z | Network |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC | OCD | |||||||||||
| TD-EF > TD-negative IF | ||||||||||||
| Inferior frontal/dorsal insula (R) | n/a | 36 | 48 | 10 | 12 | 3.6 | None | |||||
| Middle frontal (L) | n/a | 21 | −32 | 30 | 18 | 3.3 | None | |||||
| Superior temporal (R) | n/a | 29 | 52 | −46 | 16 | 2.9 | None | |||||
| Superior occipital/precuneus (L) | 7, 19, 31 | 54 | −16 | −76 | 28 | 3.9 | 84 | −32 | −86 | 26 | 4.3 | TPN |
| Superior occipital/cuneus (R) | 19, 31 | 44 | 24 | −84 | 24 | 3.6 | TPN | |||||
| Middle occipital (R) | 19, 39 | 70 | 38 | −68 | 14 | 4.1 | 79 | 42 | −78 | 10 | 3.1 | TPN |
| Middle occipital (L) | N/A | 29 | −34 | −72 | 6 | 4.0 | None | |||||
| Middle temporal/occipital (R) | 19, 37 | 77 | 54 | −60 | −2 | 3.1 | TPN | |||||
| Lingual/inferior occipital (B) | 18 | 461 | −6 | −80 | −8 | 4.2 | TPN | |||||
| Lingual/cerebellum (B) | 18 | 387 | 16 | −90 | 22 | 3.9 | TPN | |||||
| Lingual/cerebellum (R) | 18, 19 | 260 | 18 | −70 | −20 | 3.8 | TPN | |||||
| Fusiform/cerebellum (R) | 45 | 24 | −50 | −18 | 3.4 | None | ||||||
| TD-EF > TD-positive IF | ||||||||||||
| DLPFC (R) | 46 | 28 | 42 | 34 | 14 | 2.8 | TPN | |||||
| Superior frontal (R) | 8 | 23 | 22 | 14 | 52 | 3.6 | DMN, TPN | |||||
| Precentral (R) | 6 | 91 | 42 | −6 | 38 | 3.5 | TPN | |||||
| Inferior frontal/precentral (R) | 44 | 44 | 50 | 10 | 12 | 3.0 | TPN | |||||
| Anterior cingulate (L) | 24, 32 | 39 | −14 | 10 | 36 | 3.9 | None | |||||
| Mid-cingulate (L) | 24 | 34 | −16 | −8 | 42 | 3.5 | TPN | |||||
| Mid-insula/superior temporal (R) | 22 | 28 | 50 | 0 | 2 | 3.2 | None | |||||
| Middle temporal/occipital (R) | 19, 37, 39 | 78 | 42 | −68 | 14 | 4.2 | DMN, TPN | |||||
| 71 | 50 | −62 | −2 | 3.5 | TPN | |||||||
| Middle occipital/temporal (R) | 19 | 192 | 36 | −84 | 8 | 3.7 | TPN | |||||
| Middle occipital/angular gyrus (L) | 39 | 75 | −32 | −76 | 26 | 3.3 | DMN, TPN | |||||
| Precuenus (L) | 31 | 22 | −22 | −72 | 18 | 3.4 | None | |||||
| PCC/cuneus (R) | 30 | 52 | 22 | −64 | 8 | 3.6 | None | |||||
| Cuneus/superior occipital (L) | 7, 18, 19 | 185 | −12 | −88 | 22 | 3.8 | TPN | |||||
| Cuneus (R) | 18, 19 | 25 | 6 | −88 | 26 | 3.0 | 116 | 14 | −90 | 24 | 3.4 | TPN |
| Lingual/inferior occipital (B) | 18 | 95 | 2 | −78 | 0 | 4.0 | 21 | −20 | −76 | −14 | 3.0 | None |
| 20 | −18 | −72 | 2 | 2.9 | TPN | |||||||
| 194 | −2 | −74 | −6 | 3.9 | TPN | |||||||
| TD-negative IF > TD-EF | ||||||||||||
| Caudate (R) | n/a | 25 | 12 | 18 | 12 | 3.1 | None | |||||
| Temporal pole (R) | 38 | 34 | 38 | 8 | −40 | 3.5 | None | |||||
| Lingual/inferior occipital (L) | 17, 18 | 166 | −20 | −90 | −6 | 4.0 | 24 | −18 | −94 | −12 | 3.4 | None |
| 20 | −24 | −98 | 4 | 3.4 | TPN | |||||||
| Cuenus (R) | 17 | 22 | 18 | −96 | −4 | 2.8 | 48 | 18 | −98 | −4 | 4.1 | TPN |
| TD-positive IF > TD-EF | ||||||||||||
| Posterior insula (L) | 13 | 21 | −36 | −22 | 22 | 3.3 | None | |||||
| Caudate/corpus callosum | n/a | 22 | 2 | −6 | 18 | 3.1 | TPN | |||||
| Hippocampus/PG | 27 | 43 | −18 | −40 | 4 | 3.3 | DMN | |||||
| PCC/cuneus (L) | n/a | 23 | −22 | −54 | 26 | 3.5 | None | |||||
| Middle occipital (R) | n/a | 21 | 26 | −68 | 6 | 4.1 | None | |||||
| Lingual/cuneus (R) | 17, 18 | 101 | 20 | −98 | −4 | 3.7 | 58 | 20 | −98 | −4 | 3.5 | TPN |
| Lingual/inferior occipital (L) | 17, 18 | 45 | −18 | −90 | −4 | 3.5 | 28 | −24 | −96 | 2 | 3.3 | TPN |
TD-EF=TD following external focus; TD-negative IF=TD following negative internal focus; TD-positive IF=TD following positive internal focus; DLPFC=dorsolateral prefrontal cortex; PG=parahippocampal gyrus; PCC=posterior cingulate cortex.
BA=Brodmann's areas; k=number of voxels; L=left; R=right; B=both hemispheres; coordinates are in MNI space. “Network” column indicates to which of two intrinsic networks identified in a separate resting-state functional connectivity data set, if any, each cluster belongs (see Fig. S1, default mode network: DMN, task-positive network: TPN). Data are thresholded at p < 0.005/k=20 (uncorr). There were no whole-brain corrected effects (see Supplement S3.3).