miR-216a, miR-216b, and miR-217 expression in control and transgenic mice. The miR-216a (a), miR-216b (b), and miR-217 (c) expression is shown in young and old P48+/Cre;LSL-KRASG12D, old PDX-1-Cre;LSL-KRASG12D, and control mice. d Pancreatic expression of miR-216a, miR-216b, and miR-217 in Elas KrasG12D mice. Mean ± S.E.M. *P < 0.05, **P < 0.01 compared to control