Table 1.

Synopsis of physician cases

Case	Medical specialty	Age at symptom onset	Sex	Statin	Dose (mg)	Risk factors	Adverse effect	Naranjo causality
Dr. A	Radiology	50s	M	Atorvastatin	40,80	High dose^a	Cognitive	6 Probable
							Neuropathy
							Glucose intolerance
Dr. B	Internal medicine	40s	M	Atorvastatin	10	^c	Muscle weakness	5 Probable
Dr. B	Internal medicine	40s	M	Atorvastatin	10	^c	Myalgia	5 Probable
Dr. C	Cardiac surgery	40s	M	Atorvastatin	20, 40	High dose^a; combination with other lipid lowering agent	Irritability	7 Probable
							Myalgia
							Fatigue
				Ezetimibe/Simvastatin	10/40
				Rosuvastatin	20, 40
Dr. D	Emergency Medicine	50s (start statins)	M	Simvastatin	20, 40	Familial risk, high dose^a	Mitochondriopathy	9 Definite
		50s (start statins)	M	Simvastatin	20, 40	Familial risk, high dose^a	Myopathy
		60s (max symptoms)					Neuropathy
		60s (max symptoms)					Exercise intolerance
Dr. E	Physical medicine and rehab	50s	M	Simvastatin	20	Active athlete; combination with other lipid lowering agent	Muscle weakness	5 Probable
				Simvastatin	20		Myalgia
				Niacin	1500		Myalgia
Dr. F	OB/Gyn	70s	M	Lovastatin	20	Diabetes	Muscle weakness	9 Definite
				Lovastatin	20		Myalgia
				Simvastatin	20
				Atorvastatin	20
				Rosuvastatin	5
				Niacin	20
				Ezetimibe	10
Dr. G	Radiology	80s	F	Ezetimibe/simvastatin Atorvastatin	^c	Age, female, PAD^b	Cognitive	7 Probable
Dr. G	Radiology	80s	F	Ezetimibe/simvastatin Atorvastatin	^c	Age, female, PAD^b	Cognitive	7 Probable

M male, F female, OB/Gyn obstetrics and gynecology, PAD peripheral arterial disease

^aHigh dose defined as the potency equivalent of simvastatin 40 mg or higher

^bLinked to oxidative stress, mitochondrial dysfunction, and all Metabolic Syndrome factors, which in turn are risk factors

^cNot known