Table 2.

Summary of studies each of which included ≥ 100 patients who underwent hepatectomy for non-colorectal non-neuroendocrine liver metastases (disease-free survival)

Ref.	Year	No. of patients	MDFST (mo)	3-ydfsr (%)	5-ydfsr (%)	Factors associated with worse disease-free survival
Elias et al[7]	1998	1201	NR	NR	282	NR
Yedibela et al[9]	2005	1501	NR	NR	NR	NR
Weitz et al[8]	2005	141	17	30	NR	Primary tumor, diseas-free interval ≤ 24 mo
Adam et al[10]	2006	1452	13	27	21	NR
Lendoire et al[11]	2007	106	NR	NR	NR	NR
O'Rourke et al[12]	2008	102	18	37	27	Diameter of liver metastasis > 5 cm, extrahepatic nodal disease
Groeschl et al[13]	2012	420	NR	NR	NR	NR
Takemura et al[14]	2013	145	10	21	18	Blood transfusuion, preoperative chemotherapy
Hoffmann et al[15]	2015	150	21	36	29	NR
Schiergens et al[16]	2016	167	15	NR	NR	> 3 liver metastases, extrahepatic disease, residual tumor (R1,2)

¹Patients with neuroendocrine tumors were excluded;

²Results including neuroendocrine tumors. MDFST: Median disease-free survival time; ydfsr: Year disease-free survival ratio; NR: Not reported.