Table 6.
Univariate and multivariate analysis of factors contributing to SVR24 (simeprevir)
| Factors |
Univariate analysis |
Multivariate analysis |
||
| Odds ratio (95%CI) | P value | Odds ratio (95%CI) | P value | |
| Age | 0.998 (0.942-1.058) | 0.953 | ||
| Gender (female) | 0.330 (0.083-1.314) | 0.116 | ||
| Body mass index (kg/m2) | 1.164 (0.934-1.450) | 0.175 | ||
| Prior treatment response (non-NR) | 2.955 (0.811-10.764) | 0.101 | ||
| Baseline HCV-RNA (log IU/mL) | 0.767 (0.328-1.791) | 0.540 | ||
| Baseline ALT (IU/mL) | 0.998 (0.985-1.012) | 0.785 | ||
| Baseline platelets (× 104/mm3) | 1.082 (0.953-1.228) | 0.224 | ||
| Baseline hemoglobin (g/dL) | 1.257 (0.827-1.910) | 0.285 | ||
| IL28B SNP (TT) | 12.593 (1.516-104.576) | 0.019 | 9.677 (1.114-84.087) | 0.040 |
| SMV/BW (mg/kg per day) | 0.306 (0.054-1.742) | 0.182 | ||
| RBV/BW (mg/kg per day) | 1.085 (1.138-3.913) | 0.501 | ||
| PEG-IFN dose reduction (none) | 7.250 (1.712-30.700) | 0.007 | 6.557 (1.328-32.377) | 0.021 |
| RBV dose reduction (none) | 1.556 (0.470-5.160) | 0.470 | ||
| RVR (none) | 0.351 (0.075-1.637) | 0.183 | ||
HCV: Hepatitis C virus; ALT: Alanine aminotransferase; NR: Non-responder; IL28B SNP: Interleukin-28B single nucleotide polymorphism; SMV: Simeprevir; BW: Bodyweight; PEG-IFN: Pegylated interferon; RBV: Ribavirin; RVR: Rapid virological response.