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. 2017 Feb 16;8:14205. doi: 10.1038/ncomms14205

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Copyright © 2017, The Author(s)

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Ribbon representations of (a) NavMs activated, (b) NavAb pre-activated and (c) TPC1 resting state channels, including side chains of the residues in S1, S2 and S3 which form ion pairs with the S4 arginine residues. (d) Sequence alignments of the NavMs, NavAb, NavAb-Nav1.7DIV chimera, NavRh, TPC1 domain II, human Nav1.7DIV and NaChBac VS sequences (colour-coded by pairings as in a–c) with their corresponding partners. Crosslinked positions in NaChBac from ref. 11 are annotated by arrows below the sequences.