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. 2017 Feb 14;8:14043. doi: 10.1038/ncomms14043

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The approach explores the potential of a common substrate, supporting a privileged oxindole ring system and carrying enyne functional groups that can be influenced differently to follow distinct reaction pathways and thereby generating distinct scaffolds. In particular, ligand variations in the catalytic gold complex can steer the common spirooxindole gold carbene intermediate, formed by gold(I)-mediated 6-endo-dig cycloisomerization, to different rearrangements and leading to diverse scaffolds. Het, heterocycle.