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. 2017 Feb 14;8:14043. doi: 10.1038/ncomms14043

Figure 2. A collection of diverse small molecules obtained via LDS appraoch.

Figure 2

(a) Synthesis of spirooxindoles 2: 1,6-enynes 1 (0.1 M), V (0.5 mol%), DCM and 0 °C to rt, overnight. (b) Synthesis of quinolones 3: 1,6-enynes 1 (0.1 M), III (0.5 mol%) and DCM, 0 °C to rt, overnight. (c) Synthesis of df-oxindoles 4: 1,6-enynes 1 (0.1 M), MeOH (10 eq), II (0.5 mol%), DCE and rt to 60 °C, overnight. Bn, benzyl; DCE, dichloroethane; eq, equivalent; LDS, ligand-directed divergent synthesis; PMB, p-phenoxy benzyl; rt, room temperature.