Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 20;7:41416. doi: 10.1038/srep41416

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) TPC1 cancer cells migrated significantly faster towards Thyroid MSCs than PTC MSCs. Representative high-power fields from Matrigel shown. (B) Increased SOD3 expression in Thyroid MSCs significantly decreased TPC1 cell migration. Representative high-power fields from Matrigel are shown. (C) Reduced SOD3 expression reduced TPC1 cell migration toward PTC MSCs. Representative high-power fields from Matrigel are shown. (D) IL1α expression was significantly decreased in the PTC MSCs compared to the Thyroid MSCs. SOD3 over-expression in Thyroid MSCs significantly reduced IL1α mRNA synthesis compared to the Thyroid MSC control. (E) MCP1 mRNA expression was significantly decreased in PTC MSCs compared to Thyroid MSCs. SOD3 over-expression in the Thyroid MSCs significantly reduced MCP1 mRNA synthesis compared to the Thyroid MSC control. (F) IL8 mRNA expression was significantly decreased in the PTC MSCs compared to the Thyroid MSCs. SOD3 over-expression in the Thyroid MSCs did not affect IL8 expression. (G) MCP1 Western blot confirmed decreased MCP1 mRNA expression in the PTC MSCs compared to the Thyroid MSCs. (H) Flow cytometer analysis of IL8 expression confirmed decreased IL8 mRNA expression in the PTC MSCs compared to Thyroid MSCs. (I) Percentage of positive cells in the IL8 flow cytometer analysis. The p-values (*p < 0.05, **p < 0.01, ***p < 0.001) were determined by two-tail independent samples t-tests.