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. 2017 Feb 20;7:42853. doi: 10.1038/srep42853

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The diagram summarized the two proposed mechanisms governing the nucleocytoplasmic distribution mechanism of DDX6 in this study. (a) The “hitchhiking” model refers to that DDX6 can enter cell nuclei as a passenger on the mitotic chromosomes. (b) The “piggyback” model refers to that 4E-T is sufficient to transport DDX6 via the importin-α/β and the CRM1 pathways in a piggyback manner.