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. 2017 Feb 20;7:42481. doi: 10.1038/srep42481

Figure 9. Effect of IVM on homomeric GluClβ receptors.

Figure 9

(A) Representative current traces obtained by the indicated application protocol. Glu (100 mM) was applied for either 350 ms to obtain peak IP0 at −60 mV, or 600 ms to obtain peaks IP1, IP2 and IP3 at +60 mV. Note that the responses at both membrane voltages, −60 and +60 mV, start to desensitize appreciably before the end of Glu application. IVM (2 μM) was applied for 10 seconds. Asterisk indicates a 25-sec-long wash between the second and third Glu applications. (B) Current-voltage (I/V) relations obtained in a different cell than in A upon the application of Glu (100 mM) over a voltage ramp lasting 200 ms. (C) Normalized ACh response (y-axis) calculated by the current peak ratios that are indicated below the x-axis. Current ratios were extracted from experiments performed as shown in (A). Mean ± SEM of four cells are presented. Paired, two-tailed Student’s t-tests indicate that **0.001 < P < 0.01 and ***P < 0.0002.