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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Proteins. 2016 Oct 25;84(12):1929–1937. doi: 10.1002/prot.25176

Figure 4. H221R mutation impacts the gating kinetics of Kir2.1.

Figure 4

(a) represents the time course of reactivation (PIP2 re-phosphorylation, a 4-fold effect) and inhibition (PIP2 de-phosphorylation induced by Ci-VSP in a 4-fold effect) of WT-Kir2.1 and H221R; (b) Bars in b are the time constants (mean ± SEM of at least six experiments) corresponding to a.