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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 12;59(8):3840–3853. doi: 10.1021/acs.jmedchem.6b00003

Scheme 2a.

Scheme 2a

a Reagents and conditions: (a) i. SOCl2, reflux, 2 h; ii. PhNH2, K2CO3, THF, room temp., 24 h; (b) i. n-BuLi, THF, −78 °C (0.5 h) to 0 °C (0.5 h); ii. DMF, −78 °C (1 h) to 0 °C (1 h); (c) NaBH4, MeOH, room temp., 5 h; (d) 15% HCl, 60 °C, 2 d; (e) NBS, AIBN, CCl4, CH2Cl2, reflux, 2 d; (f) H2O, reflux, 2 h; (g) i. NaOMe, MeOH, EtOAc, reflux, 15 h, then HCl; ii. Ac2O, reflux, 6 h.