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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: J Med Chem. 2016 Apr 12;59(8):3840–3853. doi: 10.1021/acs.jmedchem.6b00003

Table 3.

Top1 Poisoning and Antiproliferative Activities of Indenoisoquinolines 62–66

compd Top1 MGM GI50 (μM)a
62 ++ 15.1
63 ++++ 1.86
64 +++ 1.86
65 +++ 8.71
66 +++ 0.32 ± 0.23
a

Mean graph midpoint GI50 from the NCI-60 five-concentration assay.