Figure 2.

Neutrophils are the main cells responsible for PTBsig. (a) and (b): hierarchical clustering of the pPTBsigs with PTBsigs in Test_set_separated (a) and Training_set (b). HC_Neut = PTBsigs in neutrophils of HC donors. pHC = pPTBsigs based on the four cell populations from HC donors in Test_set_separated with no exchange of cell proportions. pHC_Mono::Neut = pPTBsigs based on the four cell populations from HC donors in Test_set_separated with the exchange of cell proportions between neutrophils and monocytes. The other pPTBsig names were derived by the similar abbreviation. (c) and (Table 1): plots of the relative global responses of the four cell populations in PTB patients (c) and their correlation analysis with PTBsig (Table 1).