Table 1.

Summary of IBD associated AA cases from the literature database and our search at St. Michael's Hospital.

Study/patient ID	Age/sex	IBD phenotype (CD/UC/IC)	Age of IBD diagnosis/temporal relation to diagnosis of AA	IBD flare during AA	Symptoms	Location of AA	Other IBD EIM	Antibiotic treatment	Corticosteroids	Additional immunotherapy	Surgical procedures	Maintenance therapy after diagnosis of AA	Number of relapses
André et al. 2007 [5]∗/1–21	Mean 24.4 (range 10–54)/12 F & 9 M	17CD, 3UC, 1IC	Average age of IBD onset = 23.7 (range 12–38)/before (n = 7), concomitant (n = 7), after (n = 7)	Yes (n = 8), no (n = 13)	Fever (n = 19), abdominal pain (n = 17), weight loss (n = 10), diarrhea (n = 5)	Spleen alone (n = 6) or spleen and lymph nodes (n = 4); pharynx and cervical muscles (n = 1); liver (n = 1); liver and lymph nodes (n = 3); kidney (n = 1), and lymph nodes alone (n = 4)	Arthritis (x4), myalgia (x5), ND (x2), aphthous ulcer (x7)	Yes (n = 21)	Yes (n = 21)	Total (n = 10), cyclophosphamide (n = 3), azathioprine (n = 7), methotrexate (n = 1), infliximab (n = 2)	Splenectomy (n = 9)	Information not provided	Mean = 1.38 (n = 12), range 0–5
Lamport et al. [6]/22	38/F	CD	34/before	No	Leg weakness	Bilateral psoas muscle and epidural	—	Yes	Yes	—	—	—	1
Actis et al. [7]/23	30/M	CD	30/after	Yes	Fever, diarrhea, abdominal pain	Spleen, abdominal lymph nodes	Panniculitis, polyneuropathy	Yes	Yes	Azathioprine	Splenectomy and lymph node excision	Prednisone (stopped after 4th relapse), azathioprine (after last relapse)	4
Tirpitz et al. [8]/24	80/F	UC	72/before	Yes	Abdominal pain, abdominal swelling, bloody diarrhea	Bi-temporal upper eyelids	Pyoderma gangrenosum	Yes	Yes	—	—	Prednisone, sulfasalazine	0
Murata et al. [9]/25	18/F	UC	15/before	No	Fever	Sternum	Arthritis	Yes	Yes	—	I&D	—	4
Hara et al. [10]/26	39/M	UC	34/before	No	Painful facial lesions, fever, nonbloody diarrhea	SC scalp, face, right inner canthus, submaxilla, and chest	Arthritis	Yes	Yes	—	I&D	Sulfasalazine (after relapse)	1
Coat et al. [11]/27	31/F	CD	28/before	Yes	Fever, back pain	Spleen	—	Yes	Yes	Azathioprine	Splenectomy	—	1
Kinjo et al. [12]/28	34/F	UC	31/before	Yes	Fever, bloody stool	SC sternum	Arthritis	No	Yes	—	I&D	—	1
Holstein et al. [13]/29	26/M	CD	24/before	No	Fever, diarrhea, weight loss, weakness, loss of appetite	Liver, spleen	HLA B27 sacroiliitis, Arthritis	Yes	Yes	Azathioprine	Splenectomy	Azathioprine (after 3rd relapse)	3
Li et al. [14]/30	39/F	UC	26/before	Yes	Fever, bloody diarrhea, abdominal pain	SC left forearm	Arthritis	Yes	Yes	—	I&D	—	0
Coyne [15]/31	34/M	CD	33/before	No	Abdominal pain	Spleen	—	No	No	—	Splenectomy	—	0
Renna et al. [16]/32	20/F	CD	20/concomitant	Yes	Fever, abdominal pain, nonbloody diarrhea, weight loss	Spleen	—	Yes	Yes	—	Splenectomy	Prednisone (before, during, and after relapse)	1
Zakout et al. [17]/33	29/F	CD	29/concomitant	Yes	Fever, abdominal pain, pain in right shoulder radiating from abdomen, right pleuritic chest pain, nonbloody diarrhea	Liver	—	Yes	No	Azathioprine	—	Azathioprine, sulfasalazine	0
Yilmaz et al. [18]/34	34/F	UC	22/before	Yes	Fever, nasal ache, difficulty with breathing	Nasal septum	—	Yes	Yes	—	I&D	—	0
Brooks and Ghaffari [19]/35	19/F	CD	19/concomitant	Yes	Abdominal pain	Spleen	Pustular skin lesions	Yes	Yes	Azathioprine	—	Azathioprine	0
Sakharpe et al. [20]/36	48/F	CD	Unknown/before	No	Fever, weakness, loss of appetite, coughing, chest pain	Liver	—	No	Yes	—	—	—	0
Boschetti et al. [21]/37	40/F	CD	Unknown/after	No	Fever, abdominal pain	Spleen, pancreas	Sweet's syndrome	Yes	Yes	Adalimumab	Laparoscopic biopsy of mesenteric lymph nodes	Adalimumab	0
Bollegala et al./case 1	33/M	UC	18/before	Yes	Abdominal pain, fever, weight loss, sweat	Spleen	Pyoderma gangrenosum	Yes	Yes	Infliximab	—	Prednisone & 5-ASA (before relapse), infliximab (after relapse)	1
Bollegala et al./case 2	27/F	UC	26/before	No	Abdominal pain, chest pain radiating to left shoulder, fever, weight loss	Spleen	Sweet's syndrome, oral ulcers, arthritis	No	No	Infliximab	Splenectomy	Infliximab	0

AA = aseptic abscess, CD = Crohn's disease, EIM = extraintestinal manifestation, F = female, IC = indeterminate colitis, IBD = inflammatory bowel disease, I&D = incision and drainage, M = male, ND = neutrophilic dermatosis, SC = subcutaneous, UC = ulcerative colitis.

^∗Case series summary data available.