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. Author manuscript; available in PMC: 2017 Feb 20.
Published in final edited form as: Mol Neurobiol. 2015 Dec 10;53(10):6698–6708. doi: 10.1007/s12035-015-9601-8

Fig. 1.

Fig. 1

The generation and application of iPSCs in HD research. HD patient-specific iPSCs can be obtained by reprogramming of skin fibroblasts. Established iPSCs can be used as a tool for better understanding the molecular basis of HD. iPSC technology can also be coupled with high-throughput screening that provides a more efficacious platform to assess novel drug candidates aimed at stopping or slowing disease process. Moreover, HD-iPSCs can be differentiated into specific cell types predominantly affected in the disease (striatal MSNs). Emerging gene therapies make the genetic correction of HD-iPSCs become feasible, paving the way for autologous transplantation strategies of healthy iPSCs or iPSC-derived neural cells